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Endosome-Mitochondria Interface Controls Intracellular Iron Trafficking in Erythroid Cells
(American Society of Hematology, 2016-01)In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2+ into protoporphyrin IX. However, the path of iron from endosomes to mitochondrial ferrochelatase remains ... -
Heme Synthesis Is Inhibited in Erythroid Cells Derived from Beta-Thalassemic Mice
(Elsevier, 2017-12)Thalassemias are a heterogeneous group of red blood cell disorders characterized by ineffective erythropoiesis, peripheral hemolysis and anemia. Transfusion-dependent thalassemia (TDT) includes thalassemia major patients ... -
Transcriptional regulation of transferrin receptor by heme in erythroid cells
(Elsevier, 2014-09)Hemoglobin synthesis consumes most of the iron that is taken up by cells from plasma transferrin, and this process requires very high expression of transferrin receptors (TfR) at the membranes of erythroid cells. In contrast ... -
Interaction of Transferrin-Endosomes with Mitochondria: Implications for Iron Transport to Ferrochelatase in Erythroid Cells
(American Society of Hematology, 2015-12)Delivery of iron (Fe) to most cells occurs following the binding of diferric transferrin (Tf) to its cognate receptors on the cell membrane following which the Tf-receptor complexes are internalized via endocytosis. Iron ... -
Heme Oxygenase 1 Inhibition Reverses Anemia in β-Thalassemia Mice
(American Society of Hematology, 2016-01)Thalassemias are a heterogeneous group of red blood cell (RBC) disorders ranging from a clinically severe phenotype requiring lifesaving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, ... -
Pathophysiology and treatment of beta-thalassemia: Investigations of heme oxygenase 1 and its inhibitors
(American Society of Hematology, 2015-12)Thalassemias are a heterogeneous group of red blood cell disorders ranging from a clinically severe phenotype requiring life-saving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, sometimes ... -
Transcriptional induction of transferrin receptors by heme in erythroid cells
(American Society of Hematology, 2015-12)The transferrin receptor (TfR) is a membrane glycoprotein whose only clearly defined function is to mediate cellular uptake of iron (Fe) from a plasma glycoprotein, transferrin. Iron uptake from diferric transferrin (Tf) ... -
Role of heme in the regulation of transferrin receptor expression in erythroid cells
(American Society of Hematology, 2017-12)Physiologically, iron is transported between sites of absorption, storage, and use by the plasma glycoprotein transferrin (Tf). Most cells acquire iron via the binding of Tf to the Tf receptor (TfR) on the cell membrane. ... -
Further Elucidation of the Mechanism of Iron Transport Form Plasma Transferrin to Mitochondrial Ferrochelatase: Further Evidence for the “Kiss and Run” Hypothesis
(American Society of Hematology, 2014-11)Normal hemoglobinization of immature red blood cells (RBC) requires iron (Fe) uptake from transferrin (Tf), mediated by Tf receptors (TfR). Following the binding of Fe(III)2-Tf to TfR on the erythroid cell membrane, the ... -
Asparagus saponins: chemical characterization, bioavailability and intervention in human health
(Juniper Publishers, 2018-07)In the last years, there has been increasing interest in the research on saponins from food sources. Many epidemiological studies have pointed out their versatile health benefits. Since saponins are directly associated ... -
Nutritional composition and antioxidant activity of different walnut varieties (Juglans regia L.) from Nerpio (Spain) in comparison to commercial varieties
(Consejo Superior de Investigaciones Científicas, 2019)In the Nerpio region (Albacete, Spain), endogenous walnut cultivars have been grown since ancient times. None of them has been chemically characterized to valorize them in comparison to commercial varieties. In this work, ... -
Tampering with Cell Division by Using Small‐Molecule Inhibitors of CDK–CKS Protein Interactions
(wiley, 2015-02)Cyclin-dependent kinases (CDKs) control many cellular processes and are considered important therapeutic targets. Large collections of inhibitors targeting CDK active sites have been discovered, but their use in chemical ... -
A small molecule screen in yeast identifies inhibitors targeting protein–protein interactions within the vaccinia virus replication complex
(Elsevier, 2012-11)Genetic and biochemical data have identified at least four viral proteins essential for vaccinia virus (VACV) DNA synthesis: the DNA polymerase E9, its processivity factor (the heterodimer A20/D4) and the primase/helicase ... -
Antioxidant and hepatoprotective effects of Asparagus albus leaves in carbon tetrachloride‐induced liver injury rats
(Wiley Online Library, 2018-02)The antioxidant and hepatoprotective activities of hot aqueous extract from Asparagus albus (A. albus) leaf against CCl4-induced liver damage in rats were investigated. The total phenolic, flavonoid, and condensed tannin ... -
The phytochemical and bioactivity profiles of wild Asparagus albus L. plant
(Elsevier, 2017-09)The ethanolic extracts from the leaves, pericarps and rhizomes of Asparagus albus L. were investigated for their phytochemical composition, antioxidant (DPPH and FRAP assays), anti-microbial against human pathogenic isolates ... -
Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model
(American Society of Hematology, 2018-01)Thalassemias are a heterogeneous group of red blood cell disorders, considered a major cause of morbidity and mortality among genetic diseases. However, there is still no universally available cure for thalassemias. The ... -
First BRET‐based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors
(Biotechnology Journal, 2011-07)The protein kinase CDK5 (cyclin-dependent kinase 5) is activated through its association with a cyclin-like protein p35 or p39. In pathological conditions (such as Alzheimer's disease and various other neuropathies), ... -
Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin
(Nature Publishing Group, 2019-06)Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) ... -
Erythroid cell mitochondria receive endosomal iron by a “kiss-and-run” mechanism
(Elsevier, 2016-12)In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2 + into protoporphyrin IX. However, the path of iron from endosomes to mitochondrial ferrochelatase remains ... -
Yeast two-hybrid methods and their applications in drug discovery
(Elsevier, 2012-02)The yeast two-hybrid (Y2H) method was first described over 20 years ago. It soon appeared as a major methodological breakthrough in the discovery and analysis of protein interactions, which play a pivotal role in all ... -
Introduction [to edited volume 'Ethnicity, disability, and chronic illness']
(Open University Press, 2000-01) -
Making black people sick:‘race’, ideology and health research
(Open University Press, 1993)Race' and health research is a major industry. However, its benefits to ethnic minorities in terms of understanding illness or improving health care are minimal (Bhopal 1992; Sheldon and Parker 1992). The literature is ... -
Do they look after their own? Informal support for South Asian carers
(Blackwell Science Ltd, 2004-08)Policy on care in the community was founded on the premise that the care of frail elderly people with disabilities would be a joint responsibility for health and social care professionals, and family carers, supported by ... -
An examination of two dimensions of physician perceived value on physician satisfaction in the Yemeni pharmaceutical industry
(ResearchGate, 2014-06)This paper explores the relationship between dimensions of perceived value by the physician and his level of satisfaction in the pharmaceutical industry in Yemen. The two dimensions of customer perceived value, namely, ... -
Investigating the Impact of Marketing Mix Strategies on Physicians' Satisfaction in the Yemeni Pharmaceutical Industry
(ResearchGate, 2014-02)Previous studies have paid much attention on marketing mix strategy and customer satisfaction, but none has explored in pharmaceutical industry. This study fills this research gap. The main purpose of this study is to ... -
A multiparametric MRI-based CAD system for accurate diagnosis of bladder cancer staging
(ELSEVIER, 2021-03)Appropriate treatment of bladder cancer (BC) is widely based on accurate and early BC staging. In this paper, a multiparametric computer-aided diagnostic (MP-CAD) system is developed to differentiate between BC staging, ... -
A novel technology to integrate imaging and clinical markers for non-invasive diagnosis of lung cancer
(Scientific reports, 2021-02)This study presents a non-invasive, automated, clinical diagnostic system for early diagnosis of lung cancer that integrates imaging data from a single computed tomography scan and breath bio-markers obtained from a single ... -
Coping With Social Distancing: A Survival Guide For Teaching During The Coronapocalypse.
(2020)Social distancing: It’s not about you, it’sabout us Social distancing, quarantines and isolation are being used to contain the coronavirus pandemic and limit its impact on public health. -
The Fear Endemic Of Covid-19: Myths, Conspiracy Theories And Cybercrime In The Coronavirus Multiverse
(2020)From a risk communications perspective, using the name SARS can have unintended consequences in terms of creating unnecessary fear for some populations, especially in Asia which was worst affected by the SARS outbreak in ... -
What’s Wrong With the ‘War on Obesity?’ A Narrative Review of the Weight-Centered Health Paradigm and Development of the 3C Framework to Build Critical Competency for a Paradigm Shift
(Sage Publication, 2018)Discourse about health that focuses predominantly on body weight is referred to as the weight-centered health paradigm (WCHP). In recent years, there has been a significant increase in critical analysis of the WCHP. This ... -
Implementing Barcode Medication Administration Systems in Public Sector Medical Units
(IGI Global, 2018)Medication errors in healthcare have a high cost since it is one of the main causes of harming a patient; it leads to inefficient utilization of healthcare organization resources. The barcode medication administration ... -
3D kidney segmentation from abdominal diffusion MRI using an appearance-guided deformable boundary
(2018)A new technique for more accurate automatic segmentation of the kidney from its surrounding abdominal structures in diffusion-weighted magnetic resonance imaging (DW-MRI) is presented. This approach combines a new 3D ... -
Early diabetic retinopathy diagnosis based on local retinal blood vesselsanalysis in optical coherence tomography angiography (OCTA) images
(Wiley on line library, 2018)urpose:This paper introduces a new computer-aided diagnosis (CAD) system for detecting early-stage diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) images.Methods:The proposed DR-CAD system ... -
Design and implementation of a mobile device for blood glucose level assessment
(IEEE, 2018)In this paper, we propose a framework that catersfor diabetic patients in the UAE. The system integrates a smalland lightweight wearable device in the form of a watch witha mobile application to aid in the analysis of blood ... -
Significant Region-Based Framework for Early Diagnosis of Alzheimer's Disease Using 11C PiB-PET Scans
(International Conference on Pattern Recognition (ICPR), 2018)Alzheimer's disease (AD) is a behavioral and cognitive neurodegenerative disorder whose sufferers exceed 5.5 million Americans. Among its stages, the early diagnosis of AD is considered the main research issue due to many ... -
Alzheimer's disease diagnostics by a deeply supervised adaptable 3D convolutional network
(Cornell university, 2016)Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture ... -
A Generalized Deep Learning-Based Diagnostic System for Early Diagnosis of Various Types of Pulmonary Nodules
(Sage Publication, 2018)A novel framework for the classification of lung nodules using computed tomography scans is proposed in this article. To get an accurate diagnosis of the detected lung nodules, the proposed framework integrates the following ... -
Retracted: Early diabetic retinopathy diagnosis based on local retinal blood vessels analysis in optical coherence tomography angiography (OCTA) images
(Wiley Online Library, 2018)The above article from Medical Physics, published online on 22 February 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief and John Wiley ... -
Advantages of bioconjugated silica-coated nanoparticles as an innovative diagnosis for human toxoplasmosis.
(Elsevier, 2018)Nanotechnology is a promising arena for generating new applications in Medicine. To successfully functionalised nanoparticles for a given biomedical application, a wide range of chemical, physical and biological factors ... -
Loss, Gain, and Singular Points in Open Quantum Systems
(Hindawi, 2018)Non-Hermitian quantum physics is used successfully for the description of different puzzling experimental results, which are observed in open quantum systems. Mostly, the influence of exceptional points on the dynamical ... -
Motivators of social sustainability in healthcare supply chains in the UAE—Stakeholder perspective
(Elsevier, 2018)This paper aims to identify the dimensions of motivation for social sustainability in healthcare in the United Arab Emirates (UAE). Further, the impact of these dimensions on the motivation for social sustainability is ... -
THE CASE FOR REGULATORY REFORM IN THE BUSINESS AND HEALTHCARE ENVIRONMENTS
(SPAEF, 2009)Government regulations affect corporations and consumers on a daily basis. For example, environmental and safety regulations in the workplace are administrated by the Occupational Safety and Health Administration (OSHA) ... -
StepUp: A Step Counter Mobile Application to Promote Healthy Lifestyle
(IEEE, 2009)The Gulf States currently have one of the highest rates of diabetes and obesity in the world. It is blamed on a sedentary lifestyle and easy access to food high in fat and calories. Lifestyle choices such as physical ... -
The leapfrog effects of wireless networks for smes: preliminary findings from a community hospital
(The 9th International Conference on Electronic Business, Macau, 2009-01)This article briefly summarizes a case study that investigates how wireless networks renovate a community hospital’s competitive operations. Due to limited resources, this small community hospital failed to follow ... -
StepUp: A step counter mobile application to promote healthy lifestyle
(IEEE, 2010-03-01)The Gulf States currently have one of the highest rates of diabetes and obesity in the world. It is blamed on a sedentary lifestyle and easy access to food high in fat and calories. Lifestyle choices such as physical ... -
Harnessing social dynamics though persuasive technology to promote healthier lifestyle
(Elsevier, 2013-07-27)In light of current calls by medical professionals to confront the global issue of obesity and related illnesses, we developed a mobile application called STEP UP that monitors physical activity and provides data that can ... -
A fast stochastic framework for automatic MR brain images segmentation
(Public Library of Science, 2017-11-14)This paper introduces a new framework for the segmentation of different brain structures (white matter, gray matter, and cerebrospinal fluid) from 3D MR brain images at different life stages. The proposed segmentation ... -
Towards Remote Monitoring of Vital Signs without Body Instrumentation
(IEEE, 2017)This research presents two approaches using microwave signals to detect vital signs of humans equipped with an m-health application. The first approach utilizes phase locked loop (PLL) to multiply the frequency of a very ... -
A new deep-learning approach for early detection of shape variations in autism using structural mr
(IEEE, 2018-02-22)This paper introduces a novel shape-based computer-aided diagnosis (CAD) system using magnetic resonance (MR) brain images for autism diagnosis at different life stages. To improve the classification robustness, the system ...
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