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Handicapping Conditions among Children Under Six Years in Family Medicine Centers in Alexandria. Part II: Assessment of Resources
(NotionWave Inc., 2005-07)Handicap means the disadvantage or restriction of activity caused by disability. It is the practical consequence of disability and impairment. It is estimated that 5% of the world’s children population suffer from severe ... -
Research Article Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA)
(Hindawi, 2017)The objectives of this study were to estimate the burden of diabetes and to explore the adverse pregnancy outcomes associated with pregestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) among ... -
Liver, NAFLD and COVID-19
(Georg Thieme Verlag KG, 2022-06)Coronavirus disease 2019 (COVID-19) is characterized by a wide clinical spectrum that includes abnormalities in liver function indicative of liver damage. Conversely, people with liver diseases are at higher risk of severe ... -
COVID-19 Infections in Gonads: Consequences on Fertility?
(Georg Thieme Verlag KG, 2022-06)COVID-19 may influence human fertility and sexuality in several ways. Different cell types in gonads show a constitutive expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 ... -
Risk of aggression and criminal behaviour among adolescents living in Alexandria Governorate, Egypt
(IRIS, 2014)ABSTRACT Adolescent risk-taking and aggressive behaviours are among the most visible forms of violence in society. A study was carried out to identify the prevalence and risk factors for aggression, violence and ... -
Demographic profile and pregnancy outcomes of adolescents and older mothers in Saudi Arabia: analysis from Riyadh Mother (RAHMA) and Baby cohort study
(BMJ, 2017-09)Abstract Objectives To investigate the impact of maternal age on pregnancy outcomes with special emphasis on adolescents and older mothers and to investigate the differences in demographic profile between adolescents and ... -
Self-medication with drugs and complementary and alternative medicines in Alexandria, Egypt:prevalence, patterns and determinants
(IRIS, 2015)This study aimed to describe the prevalence, pattern and reasons for self-medication among adults in Alexandria, Egypt. In a community-based survey during 2012, a representative sample of 1100 adults completed a predesigned ... -
Prevalence and complications of pregestational and gestational diabetes in Saudi women: analysis from Riyadh Mother and Baby cohort study (RAHMA)
(Hindawi, 2017-10)The objectives of this study were to estimate the burden of diabetes and to explore the adverse pregnancy outcomes associated with pregestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) among ... -
Endosome-Mitochondria Interface Controls Intracellular Iron Trafficking in Erythroid Cells
(American Society of Hematology, 2016-01)In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2+ into protoporphyrin IX. However, the path of iron from endosomes to mitochondrial ferrochelatase remains ... -
Heme Synthesis Is Inhibited in Erythroid Cells Derived from Beta-Thalassemic Mice
(Elsevier, 2017-12)Thalassemias are a heterogeneous group of red blood cell disorders characterized by ineffective erythropoiesis, peripheral hemolysis and anemia. Transfusion-dependent thalassemia (TDT) includes thalassemia major patients ... -
Transcriptional regulation of transferrin receptor by heme in erythroid cells
(Elsevier, 2014-09)Hemoglobin synthesis consumes most of the iron that is taken up by cells from plasma transferrin, and this process requires very high expression of transferrin receptors (TfR) at the membranes of erythroid cells. In contrast ... -
Interaction of Transferrin-Endosomes with Mitochondria: Implications for Iron Transport to Ferrochelatase in Erythroid Cells
(American Society of Hematology, 2015-12)Delivery of iron (Fe) to most cells occurs following the binding of diferric transferrin (Tf) to its cognate receptors on the cell membrane following which the Tf-receptor complexes are internalized via endocytosis. Iron ... -
Heme Oxygenase 1 Inhibition Reverses Anemia in β-Thalassemia Mice
(American Society of Hematology, 2016-01)Thalassemias are a heterogeneous group of red blood cell (RBC) disorders ranging from a clinically severe phenotype requiring lifesaving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, ... -
Pathophysiology and treatment of beta-thalassemia: Investigations of heme oxygenase 1 and its inhibitors
(American Society of Hematology, 2015-12)Thalassemias are a heterogeneous group of red blood cell disorders ranging from a clinically severe phenotype requiring life-saving transfusions (thalassemia major) to a relatively moderate symptomatic disorder, sometimes ... -
Transcriptional induction of transferrin receptors by heme in erythroid cells
(American Society of Hematology, 2015-12)The transferrin receptor (TfR) is a membrane glycoprotein whose only clearly defined function is to mediate cellular uptake of iron (Fe) from a plasma glycoprotein, transferrin. Iron uptake from diferric transferrin (Tf) ... -
Role of heme in the regulation of transferrin receptor expression in erythroid cells
(American Society of Hematology, 2017-12)Physiologically, iron is transported between sites of absorption, storage, and use by the plasma glycoprotein transferrin (Tf). Most cells acquire iron via the binding of Tf to the Tf receptor (TfR) on the cell membrane. ... -
Further Elucidation of the Mechanism of Iron Transport Form Plasma Transferrin to Mitochondrial Ferrochelatase: Further Evidence for the “Kiss and Run” Hypothesis
(American Society of Hematology, 2014-11)Normal hemoglobinization of immature red blood cells (RBC) requires iron (Fe) uptake from transferrin (Tf), mediated by Tf receptors (TfR). Following the binding of Fe(III)2-Tf to TfR on the erythroid cell membrane, the ... -
Asparagus saponins: chemical characterization, bioavailability and intervention in human health
(Juniper Publishers, 2018-07)In the last years, there has been increasing interest in the research on saponins from food sources. Many epidemiological studies have pointed out their versatile health benefits. Since saponins are directly associated ... -
Nutritional composition and antioxidant activity of different walnut varieties (Juglans regia L.) from Nerpio (Spain) in comparison to commercial varieties
(Consejo Superior de Investigaciones Científicas, 2019)In the Nerpio region (Albacete, Spain), endogenous walnut cultivars have been grown since ancient times. None of them has been chemically characterized to valorize them in comparison to commercial varieties. In this work, ... -
Tampering with Cell Division by Using Small‐Molecule Inhibitors of CDK–CKS Protein Interactions
(wiley, 2015-02)Cyclin-dependent kinases (CDKs) control many cellular processes and are considered important therapeutic targets. Large collections of inhibitors targeting CDK active sites have been discovered, but their use in chemical ... -
A small molecule screen in yeast identifies inhibitors targeting protein–protein interactions within the vaccinia virus replication complex
(Elsevier, 2012-11)Genetic and biochemical data have identified at least four viral proteins essential for vaccinia virus (VACV) DNA synthesis: the DNA polymerase E9, its processivity factor (the heterodimer A20/D4) and the primase/helicase ... -
Antioxidant and hepatoprotective effects of Asparagus albus leaves in carbon tetrachloride‐induced liver injury rats
(Wiley Online Library, 2018-02)The antioxidant and hepatoprotective activities of hot aqueous extract from Asparagus albus (A. albus) leaf against CCl4-induced liver damage in rats were investigated. The total phenolic, flavonoid, and condensed tannin ... -
The phytochemical and bioactivity profiles of wild Asparagus albus L. plant
(Elsevier, 2017-09)The ethanolic extracts from the leaves, pericarps and rhizomes of Asparagus albus L. were investigated for their phytochemical composition, antioxidant (DPPH and FRAP assays), anti-microbial against human pathogenic isolates ... -
Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model
(American Society of Hematology, 2018-01)Thalassemias are a heterogeneous group of red blood cell disorders, considered a major cause of morbidity and mortality among genetic diseases. However, there is still no universally available cure for thalassemias. The ... -
First BRET‐based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors
(Biotechnology Journal, 2011-07)The protein kinase CDK5 (cyclin-dependent kinase 5) is activated through its association with a cyclin-like protein p35 or p39. In pathological conditions (such as Alzheimer's disease and various other neuropathies), ... -
Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin
(Nature Publishing Group, 2019-06)Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) ... -
Erythroid cell mitochondria receive endosomal iron by a “kiss-and-run” mechanism
(Elsevier, 2016-12)In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2 + into protoporphyrin IX. However, the path of iron from endosomes to mitochondrial ferrochelatase remains ... -
Yeast two-hybrid methods and their applications in drug discovery
(Elsevier, 2012-02)The yeast two-hybrid (Y2H) method was first described over 20 years ago. It soon appeared as a major methodological breakthrough in the discovery and analysis of protein interactions, which play a pivotal role in all ... -
SOLS: A scheme for outsourced location based service
(Academic Press, 2015-10)Due to the high demand on computation and storage, location based service (LBS) providers prefer to outsource their data and services to powerful cloud service providers (CSPs). However, this mechanism brings three challenging ... -
Recent developments in hazardous pollutants removal from wastewater and water reuse within a circular economy
(Nature Publishing Group, 2022-04)Recent advances in wastewater treatment processes have resulted in high removal efficiencies for various hazardous pollutants. Nevertheless, some technologies are more suitable for targeting specific contaminants than ... -
Three‐dimensional graphene/MWCNT-MnO2 nanocomposites for high‐performance capacitive deionization (CDI) application
(Elsevier, 2022-05)Surface area and the conductivity of the electrode materials are crucial in achieving high desalination performance in capacitive deionization (CDI) applications. In this study, we have successfully fabricated 3D ... -
Fouling mechanisms in ultrafiltration under constant flux: Effect of feed spacer design
(Elsevier, 2020-09)The impact of feed spacer design on membrane fouling mechanism in ultrafiltration (UF) process under constant flux mode was systematically investigated. Thecombined intermediate pore blocking and cake filtration model was ... -
Feedstock Availability, Composition, New Potential Resources for Biohydrogen, Biomethane, and Biobutanol Production via Biotechnological Routes
(Springer, 2017)Booming population, higher standard of living, and growing industrialization continue to exert a demand for energy. The continuous and unlimited use of fossil fuels to meet the growing energy demand would deplete the finite ... -
Polydopamine-coated graphene oxide nanosheets embedded in sulfonated poly (ether sulfone) hybrid UF membranes with superior antifouling properties for water treatment
(Elsevier, 2022-04)A novel high-performance hybrid ultrafiltration (UF) membrane was fabricated by blending polydopamine-coated graphene oxide (PDGO) nanosheets with sulfonated poly(ether sulfone) (SPES) via phase inversion method and tested ... -
Covalent surface entanglement of polyvinylidene fluoride membranes with carbon nanotubes
(Pergamon, 2018-03)Polyvinylidene fluoride (PVDF) membranes play a key role in several industrial applications. Tuning the properties of these membranes enables a sharp selectivity for the target application. The goal of this work is to ... -
Synthesis of polydopamine coated tungsten oxide@ poly (vinylidene fluoride-co-hexafluoropropylene) electrospun nanofibers as multifunctional membranes for water applications
(Elsevier, 2022-01)In this work, electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) nanofiber membranes were loaded with tungsten oxide (WO3) nanoparticles, surface coated with polydopamine (PDA) hierarchical structures, ... -
Activation of PVDF membranes through facile hydroxylation of the polymeric dope
(Cambridge University Press, 2017-11)A method comprising a two-step alkali/acid treatment of poly (vinylidene fluoride) (PVDF) polymer is developed for the fabrication of flat-sheet PVDF membranes functionalized with labile hydroxyl groups. This method involves ... -
Exploiting the interplay between liquid-liquid demixing and crystallization of the PVDF membrane for membrane distillation
(Hindawi, 2018)Membrane distillation (MD) purifies water by transporting its vapor through a hydrophobic membrane. An ideal MD membrane poses high water flux and high fouling, scaling, and wetting resistances. In this study, we develop ... -
Synergistic effect of humic acid on alkali pretreatment of sugarcane bagasse for the recovery of lignin with phenomenal properties
(Pergamon, 2020-03)Lignin forms a recalcitrant structure in lignocellulosic biomass and hence huge amount of enzymes are required for disintegrating it into their subsequent components, like glucose and other by-products. Thus, the pretreatment ... -
Nanoporous hollow fiber polyethersulfone membranes for the removal of residual contaminants from treated wastewater effluent: Functional and molecular implications
(Elsevier, 2017-12)Hollow fiber membranes consisting of polyethersulfone (PES) reformed with high proportions of single bondOH, aryl-N and alkyl-F groups in nonsolvent additives were compared for the removal of residual Cr (VI), COD, and ... -
CNT/PVP blend PVDF membranes for the removal of organic pollutants from simulated treated wastewater effluent
(Elsevier, 2018)In this work, we established a simple and effective way of immobilizing CNT onto polyvinylidene fluoride (PVDF) membrane by casting dual-layer membranes. We explored two different methods of dual-layer casting: (i) layer ... -
Functional groups docking on PVDF membranes: Novel Piranha approach
(Pergamon, 2017-11)Polyvinylidene fluoride (PVDF) membranes play a key role in several industrial applications due to their favorable properties, including their high chemical stability. Tuning the properties of PVDF membranes enables a sharp ... -
Tackling membrane fouling in microalgae filtration using nylon 6, 6 nanofiber membrane
(Academic Press, 2018)Microalgae technology, if managed properly, has promising roles in solving food-water-energy nexus. The Achilles' heel is, however, to lower the costs associated with cultivation and harvesting. As a favorable technique, ... -
Thin film deposition techniques for polymeric membranes–A review
(Elsevier, 2020-09)Thin film deposition (TFD) allows for precise tuning of the chemical and physical properties of a membrane to improve performance, including the selectivity, flux, chemical resistance, and antifouling and antimicrobial ... -
On the effect of fumed silica particles on the structure, properties and application of PVDF membranes
(Elsevier, 2017-10)This study explored the impact of hydrophobic fumed silica (FS) particles as an inorganic additive in the preparation of polyvinylidenefluoride (PVDF) membranes using the phase inversion technique. PVDF membranes were ... -
PVDF/magnetite blend membranes for enhanced flux and salt rejection in membrane distillation
(Elsevier, 2018-06)This study reports on the enhancement of direct contact membrane distillation (DCMD) performance by incorporating magnetite nanoparticles (NP) in polyvinylidene fluoride (PVDF) membranes to render the membrane bulk hydrophilic ... -
Assessment and rationalization of water quality monitoring network: a multivariate statistical approach to the Kabbini River (India)
(Springer Berlin Heidelberg, 2014-09)The establishment of an efficient surface water quality monitoring (WQM) network is a critical component in the assessment, restoration and protection of river water quality. A periodic evaluation of monitoring network is ... -
Shrinkage, defect and membrane distillation performance of composite PVDF membranes
(Elsevier, 2015-11)This study addresses the importance of non-woven support (NWS) during the preparation of polyvinylidene fluoride (PVDF) membranes for membrane distillation (MD). Five different NWSs were investigated as substrate materials ... -
Leaching of PVP from PVDF/PVP blend membranes: Impacts on membrane structure and fouling in membrane bioreactors
(Springer US, 2016-05)Polyvinylidene fluoride (PVDF) membranes are widely used in membrane industry, especially for membrane bioreactors (MBRs). Many PVDF membranes contain residual polyvinyl pyrrolidone (PVP) that acts as a pore-forming additive. ... -
Fabrication of blend polyvinylidene fluoride/chitosan membranes for enhanced flux and fouling resistance
(Elsevier, 2018-01)The fabrication of polyvinylidene fluoride (PVDF) membranes was studied using chitosan as a hydrophilic additive for flux enhancement and stability. Chitosan (CS) was blended with PVDF at 0.5, 1.0, 1.5, 2.0 and 2.5% (w/w) ...
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