ADU Repository
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Numerical prediction of forces for turbulent flow around a ship rudder
(IAEA, 2004)The three dimensional Navier Stokes equations with the standard k-epsilon turbulence model are solved for incompressible turbulent flows around the ship rudder placed in a uniform flow. The solution was obtained using ... -
Mass transfer analysis of ultrafiltration using spacers based on triply periodic minimal surfaces: Effects of spacer design, directionality and voidage
(Elsevier, 2018-09)An ideal feed spacer balances high flux and low pressure drop while minimizing fouling. In this work, several feed spacer with complex triply periodic minimal surface (TPMS) geometries were designed and fabricated using ... -
3D printed spacers for organic fouling mitigation in membrane distillation
(Elsevier, 2019-08)3D printing offers the flexibility to achieve favorable spacer geometrical modification. The role of 3D printed spacers for organic fouling mitigation in direct contact membrane distillation (DCMD) is evaluated. Compared ... -
3D printed feed spacers based on triply periodic minimal surfaces for flux enhancement and biofouling mitigation in RO and UF
(Elsevier, 2018-01)In this proof of concept study, 3D printed feed spacers with complex geometries based on triply periodic minimal surfaces (TPMS) were designed and tested in reverse osmosis (RO) and ultrafiltration (UF) processes. The ... -
3D printed triply periodic minimal surfaces as spacers for enhanced heat and mass transfer in membrane distillation
(Elsevier, 2018-10)3D printing is utilized to create different feed channel spacer designs aimed at enhancing the spacer performance specifically for membrane distillation (MD) application. The novelty is the use of mathematically developed ... -
Membrane distillation research & implementation: Lessons from the past five decades
(Elsevier, 2017-12)Research on membrane distillation (MD) experienced a slow growth from the 1970s through 90s but has gained revived interest recently. Despite recent developments, MD still has to overcome several hurdles to pave its path ... -
Experiences of work-related stress among female healthcare workers during the COVID-19 public health emergency: a qualitative study in the united Arab of emirates
(Taylor & Francis, 2022-01)Frontline healthcare workers experienced high levels of psychological distress and emotional turmoil due to the changes necessitated by the COVID-19 public health emergency. Given that workplace stress can negatively ... -
Carbogen Inspiration Enhances Hemodynamic Contrast in the Cancerous Breast
(OPTICA, 2012-04)We have explored the vascular response of the breast to inspiration of Carbogen. Results show greater changes in vasoconstriction and HbSat in the tumor-bearing breast compared to the healthy contralateral breast of the ... -
Genetic diversity, drug resistance patterns and indicators of disease severity in Plasmodium vivax clinical isolates from Southern Pakistan
(eCommons@AKU, 2013)Pakistan is one of seven countries within the WHO Eastem Mediterranean region with nearly all of the population living 'at-risk' of malaria. Approximately,4.5 million people annually are infected by malaria in Pakistan. ... -
Cytokines, endothelial activation and microvascular dysfunction in acute respiratory syndrome due to Plasmodium vivax
(ELSEVIER, 2018-08)Plasmodium vivax, previously considered benign, is now recognized as capable of causing severe disease syndromes associated with fatal outcomes. Endothelial activation is associated with circulating parasites, and systemic ... -
Diagnostic Value of Gauze Filtration Technique: A Comparison with Conventional Methods in a Diagnostic Laboratory in Pakistan
(Cureus, 2018-11)Intestinal parasites cause significant morbidity and impact human development with an enormous global burden. Diagnosis of intestinal parasites by conventional methods has several limitations. The gauze filtration technique ... -
A dual-mode simultaneous bilateral optical imaging system for breast cancer detection
(IEEE, 2010-03)System design, performance characteristics and representative clinical findings are described for a second generation dynamic near-infrared optical tomography breast imager that examines both breasts simultaneously under ... -
Enhanced resting‐state dynamics of the hemoglobin signal as a novel biomarker for detection of breast cancer
(American Association of Physicists in Medicine, 2015-11)The work presented here demonstrates an application of diffuse optical tomography (DOT) to the problem of breast-cancer diagnosis. The potential for using spatial and temporal variability measures of the hemoglobin signal ... -
The impact of perceived social support during pregnancy on postpartum infant-focused anxieties: A prospective cohort study of mothers in Northern Jordan
(Taylor & Francis, 2021-10)This study aimed to evaluate the association between perceived social support during pregnancy and levels of anxiety among postpartum women using an anxiety-specific screening instrument. Using a prospective cohort design, ... -
Enhancing NY-ESO-1 antigen expression in lung cancer cells through gene hypomethylation using 5-Aza-2′-deoxycytidine
(ELSEVIER, 2018-12)NY-ESO-1 is a highly immunogenic cancer-testis antigens and it is a potential candidate for immunotherapy. Cellular expression of NY-ESO-1 gene is heterogeneous depending on the demethylation status of its promoter. Exposure ... -
PD-L1 blockade during ex vivo expansion of virus-specific T cells for the treatment of infections after allogeneic hematopoietic stem cell transplantation modulates the …
(ELSEVIER, 2018-12)Viral infection is a major cause of disease and mortality after allogeneic hematopoietic stem cell transplantation (AHSCT) in hematologic malignancies. It has been shown that adoptive transfer of expanded virus-specific T ... -
Identification of a Novel Promiscuous Anti-NY-ESO-1 Immunogenic CD4+ Peptide Containing a CD8+ T-Cell Epitope Highly Present in Metastatic Gastric Cancer Responding to Combined …
(ELSEVIER, 2019-12)Immune checkpoint inhibitors offer the prospect of long term disease control in solid tumor types. NY-ESO-1 is a cancer-testis antigen expressed by 20% of advanced gastric cancers, known to induce humoral and cellular ... -
5-AZA treatment induces cytotoxicity and in vitro expression of immunogenic NY-ESO-1 antigen in non-small lung cancer cell NCI-H1975
(ELSEVIER, 2019-12)Lung cancer is a major threat to the world and 80% of the reported cases belong to non-small cell lung cancers. Epigenetic modifications are common in lung cancers but can be reversible by using demethylating agents such ... -
Handicapping Conditions among Children Under Six Years in Family Medicine Centers in Alexandria. Part II: Assessment of Resources
(NotionWave Inc., 2005-07)Handicap means the disadvantage or restriction of activity caused by disability. It is the practical consequence of disability and impairment. It is estimated that 5% of the world’s children population suffer from severe ... -
Research Article Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA)
(Hindawi, 2017)The objectives of this study were to estimate the burden of diabetes and to explore the adverse pregnancy outcomes associated with pregestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) among ... -
Liver, NAFLD and COVID-19
(Georg Thieme Verlag KG, 2022-06)Coronavirus disease 2019 (COVID-19) is characterized by a wide clinical spectrum that includes abnormalities in liver function indicative of liver damage. Conversely, people with liver diseases are at higher risk of severe ... -
COVID-19 Infections in Gonads: Consequences on Fertility?
(Georg Thieme Verlag KG, 2022-06)COVID-19 may influence human fertility and sexuality in several ways. Different cell types in gonads show a constitutive expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 ... -
Risk of aggression and criminal behaviour among adolescents living in Alexandria Governorate, Egypt
(IRIS, 2014)ABSTRACT Adolescent risk-taking and aggressive behaviours are among the most visible forms of violence in society. A study was carried out to identify the prevalence and risk factors for aggression, violence and ... -
Demographic profile and pregnancy outcomes of adolescents and older mothers in Saudi Arabia: analysis from Riyadh Mother (RAHMA) and Baby cohort study
(BMJ, 2017-09)Abstract Objectives To investigate the impact of maternal age on pregnancy outcomes with special emphasis on adolescents and older mothers and to investigate the differences in demographic profile between adolescents and ... -
Self-medication with drugs and complementary and alternative medicines in Alexandria, Egypt:prevalence, patterns and determinants
(IRIS, 2015)This study aimed to describe the prevalence, pattern and reasons for self-medication among adults in Alexandria, Egypt. In a community-based survey during 2012, a representative sample of 1100 adults completed a predesigned ... -
Prevalence and complications of pregestational and gestational diabetes in Saudi women: analysis from Riyadh Mother and Baby cohort study (RAHMA)
(Hindawi, 2017-10)The objectives of this study were to estimate the burden of diabetes and to explore the adverse pregnancy outcomes associated with pregestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) among ... -
463 Metastatic gastric cancer patient benefiting from combined radio-immunotherapy treatment displayed sustained anti-NY-ESO-1 specific T cells and expressed important immuno …
(BMJ Specialist Journals, 2020-11)Combined radio-immunotherapy is currently being investigated to treat cancer patients. Anti-PD-1 immunotherapy offers the prospect of long-term disease control in solid tumors. Radiotherapy has the ability to promote ... -
Mo-doped CuO nanomaterial for photocatalytic degradation of water pollutants under visible light. Catalysts 2021, 11, 1198
(MDPI, 2021)Recently, metal oxide-based nano-photocatalysts have gained a great deal of attention in waste water remediation due to their outstanding properties. In this report, a novel Mo-doped CuO nanomaterial was successfully ... -
17 Predictive soluble biomarkers of immune response to checkpoint blockade in non-small cell lung cancer (NSCLC) patients
(BMJ Publishing Group LTD, 2021-11)There is limited data on the predictive biomarkers of response to immune checkpoint blockade (ICB) treatment of non-small cell lung cancer (NSCLC) patients. The main aim of this prospective study was to understand the ... -
Marketing Opportunities and Export Competitiveness of Indian Spices: An Econometric Analysis
(IISTE, 2018)The study intends to analyze the export competitiveness of Indian pepper. The variables that have been analyzed are Export, Real GDP, REER, Inflation, FDI, and Production. The results have been used to forecast the ... -
DOES INDIAN PUBLIC SECTOR AIM FOR A BETTER TALENT ACQUISITION PRACTICES: A STUDY BASED ON PUBLIC SECTOR EXPERIENCES IN INDIA
(IASET, 2018)This paper addresses the Talent Management challenges in Public Sector of India. Initially, the paper will discuss both the public and private sectors to identify the ongoing challenges and limitations taking place ... -
736 Treatment with decitabine (DAC) induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer
(ProQuest, 2021-11)Colorectal cancer (CRC) is a leading cause of cancer related deaths. Epigenetic silencing of numerous tumor suppressor genes by promoter region hypermethylation has been found in a variety of cancers including CRC. The ... -
15P Serum immune checkpoint biomarkers as predictors of response to anti-PD-1/PD-L1 treatment in non-small cell lung cancer (NSCLC) patients
(ELSEVIER, 2021-12)There is limited data on the predictive biomarkers of response to immune checkpoint blockade (ICB) treatment of non-small cell lung cancer (NSCLC) patients. The main aim of this prospective study is to understand the utility ... -
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer …
(Frontiers Media SA, 2022)Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still ... -
Contributing Factors of DKA in patients of diabetes mellitus
(PJMHS, 2022-05)The objective is to define the occurrence of contributing factors of DKA in diabetes patients. Descriptive cross sectional. At Institute of Child Health and Children’s Hospital Lahore study was conceded out from 1st May ... -
Occurrence of Autoimmune Thyroid Dysfunction in Juvenile SLE
(PJMHS, 2022-07)To define the occurrence of autoimmune thyroid dysfunction and its type i.e. sub-clinical hypothyroidism, hypothyroidism and hyperthyroidism in juvenile SLE. Study design: Cross-sectional study. Place and duration: The ... -
Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study
(Frontiers Media SA, 2023)The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: Here, we ... -
Genomics, proteomics and immunological signatures as diagnostic, predictive, and prognostic biomarkers in head and neck cancers
(Frontiers Media SA, 2023)Head and Neck Cancer (HNC) is the sixth most common cancer type accounting for approximately 900,000 cases and over 400,000 deaths annually (1). Heterogeneous malignancies involving the oral nasal cavities, paranasal ... -
Proteomic understanding of SARS-CoV-2 infection and COVID-19: Biological, diagnostic, and therapeutic perspectives
(ELSEVIER, 2023-01)The research community responded rapidly to the SARS-CoV-2 pandemic with a burst of proteomic studies to understand this new virus. We focus in this chapter on proteomic approaches and advances in the areas of the viral ... -
The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR)
(ELSEVIER, 2023-02)Dysregulated epigenetic modifications are common in lung cancer but have been reversed using demethylating agent like 5-Aza-CdR. 5-Aza-CdR induces/upregulates the NY-ESO-1 antigen in lung cancer. Therefore, we investigated ... -
Introductory Chapter: Introduction to New Insights and Recent Progress in Immune Checkpoint Inhibitors
(IntechOpen, 2023-03)Immune checkpoint inhibitor (ICI) is an established therapeutic strategy for various cancers. ICI comprises mainly of monoclonal antibodies that block immune regulatory checkpoint molecules, cytotoxic T-lymphocyte-associated ... -
Pulmonary complications of Plasmodium vivax malaria
(ELSEVIER, 2012-10)Plasmodium vivax malaria has historically been termed as benign tertian malaria. Several reports of P vivax malaria induced organ-specific complications have emerged in recent years. To study the clinical aspects of P vivax ... -
Hyper-reactive malarial splenomegaly in the absence of raised IgM antibodies
(SAGE Publications, 2013-01)Hyper-reactive malarial splenomegaly (HMS) is diagnosed by the presence of massive splenomegaly, raised IgM and antimalarial antibodies and a response to antimalarial therapy. Although malaria is endemic to Pakistan, HMS ... -
Age of presentation of febrile seizures and family history in children
(Pakistan Pediatric Association, 2014)The aims of the study were: (1) to determine the age of onset of febrile seizures in children with and without a family history of seizures, and (2) to identify the aetiology of febrile seizures. Patients and Methods: A ... -
SARS-CoV-2 S protein binding hACE2: viral entry, pathogenesis, prognosis, and potential therapeutic targets
(Preprints, 2020-09)Pneumonia cases of unknown etiology in Wuhan, China, were reported to the WHO on 31st of December 2019. Later the pathogen was reported to be a novel coronavirus designated Severe Acute Respiratory Syndrome Coronavirus 2 ... -
Hepatitis C diagnostic management gap in Pakistan—Clinicians’ knowledge impacting public health
(Springer Link, 2016-08)Hepatitis C virus (HCV) infects 10 million people in Pakistan with a prevalence rate of 4.9 %. Methods commonly used to diagnose HCV include anti-HCV and HCV RNA testing. However, HCV RNA is a molecular test that aims to ... -
Immunotherapeutic strategies in patients with advanced head and neck squamous cell carcinoma
(AME Publications, 2019-03)Most head and neck squamous cell carcinoma (HNSCC) patients present with advanced-stage disease often with significant rates of local failure and distant metastases (1). Over the past two decades, the survival rates of ... -
Cardiac disease classification using total variation denoising and morlet continuous wavelet transformation of ECG signals
(IEEE, 2018-03)Cardiac diseases (CDs) are a leading cause of death, and electrocardiogram (ECG) is the most important noninvasive method for the diagnosis of CDs. The objective of this study was to diagnose CDs using Morlet continuous ... -
Integrating the principles of evidence based medicine and evidence based public health: Impact on the quality of patient care and hospital readmission rates in Jordan
(Ubiquity Press, 2016-08)Hospital readmissions impose not only an extra burden on health care systems but impact patient health outcomes. Identifying modifiable behavioural risk factors that are possible causes of potentially avoidable readmissions ... -
Expression of CD91 in extracellular vesicles: A potential biomarker for the diagnosis of non-small cell lung cancer
(ELSEVIER, 2022-07)Lung cancer is the leading cause of death; by the time it is diagnosed, the patient is usually in late-stage grade IV. Late-stage lung cancer is mainly associated with metastasis in the liver, brain, and lymphoid tissues; ...
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